Navigation auf


Department of Quantitative Biomedicine

The Polymenidou group and collaborators detect TDP-43 seeding activity in the olfactory mucosa of FTD patients

See Fontana and Bongianni et al., Alzheimer's and Dementia

In this work, the Polymenidou group and collaborators assessed TAR DNA-binding protein 43 (TDP-43) seeding activity and aggregates detection in olfactory mucosa of patients with frontotemporal lobar degeneration with TDP-43-immunoreactive pathology (FTLD-TDP) by TDP-43 seeding amplification assay (TDP43-SAA) and immunocytochemical analysis. They demonstrate that TDP-43 aggregates can be detectable in olfactory mucosa, suggesting that their TDP43-Seeding Amplification Assay might be useful for identifying and monitoring FTLD-TDP in living patients.

Fig. 4: Distribution pattern of TDP-43 aggregates. © The Authors, 2023