Regulatory T cells (Tregs) curb excessive immune responses and dampen inflammation. Furthermore, in non-lymphoid tissues, Tregs promote tissue homeostasis, regeneration and repair. Profound understanding of the tissue-specific adaptations and functions of these Tregs might pave the way for therapeutic approaches targeting their regenerative role. In this review, the Joller group outlines their current understanding of how Tregs migrate into peripheral tissues and the factors required for their maintenance at these sites. Furthermore, tissue-specific adaptations of Tregs at barrier and immuno-privileged sites are discussed, as well as the mechanisms that regulate Tregs' function within these organs. Finally, this work outlines what is known about the interactions of Tregs with non-immune cells in the different peripheral tissues at steady state and upon challenge or tissue damage.
See Estrada Brull, Panetti & Joller, Frontiers in Immunology.