10.09.2020

The Krauthammer lab investigates topics in clinical data science and translational bioinformatics, such as knowledge discovery from Big Data sources (Electronic Medical Record), development of Natural Language processing, information retrieval and extraction routines, as well as the analysis of human Omics data. 

The group is looking to hire a Junior Research Software Engineer to expand the team’s technical capacity. In this unique role, you will work with an interdisciplinary team of researchers, biostatisticians, and data engineers to support a variety of research projects in clinical data science and bioinformatics. You will apply your unique technical and practical skills to bring research ideas to fruition, deploying data tools and visualizations in live clinical settings.

You will work on a number of research projects, including the development of clinical risk prediction tools and the creation of apps to optimise hospital resource scheduling.

More information on responsibilities, qualifications, and on how to apply can be found here

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28.07.2020

The University of Zurich together with the University Hospital of Zurich are embarking on a concerted effort to develop informatics programs to advance biomedical research using cutting edge computational approaches. As part of these efforts, the Krauthammer research group investigates topics in clinical data science and translational bioinformatics, such as knowledge discovery from Big Data sources (Electronic Medical Record), development of Natural Language processing, information retrieval and extraction routines, as well as the analysis of human Omics data. The group is headed by Prof. Michael Krauthammer and is part of the Department of Quantitative Biomedicine (DQBM).

For this position, we are looking for motivated PostDoc candidates who are interested in applying their computational skills to medical as well as biological problems. An example of Machine Learning (ML) in biology is our latest work on genome editing tools (base editors) for basic research and gene therapy. We developed BE-DICT ¹, an attention-based deep learning algorithm capable of predicting base editing outcomes with high accuracy. 

An example of ML in healthcare is our work on time series analysis for patient readmission prediction. In this work ², we explored the systematic application of neural network models for predicting 30 days all-cause readmission after discharge from a HF hospitalization.  And more recently, we are focused on the analysis of patient trajectories (i.e. using patients’ medical history) and “patient similarities” (i.e. patient similarity assessment on longitudinal health data) for care pathway/knowledge discovery, and personalized outcome prediction ³. Our goal is to develop state-of-the-art approaches and build best-in-class methods to capitalize on digital clinical information to automatically compare, analyze and visualize complex longitudinal patient journeys focusing on the concept of patient journey similarity. This involves building decision support systems powered by predictive algorithms for guiding patient therapy across all disease stages, the assessment of treatment effects using counterfactual inference and the identification of causal mechanisms driving disease progression.

1. Marquart, K. F., Allam, A., et al. Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens. bioRxiv 2020.07.05.186544 (2020) doi:10.1101/2020.07.05.186544.
2. Allam, A., Nagy, M., Thoma, G. & Krauthammer, M. Neural networks versus Logistic regression for 30 days all-cause readmission prediction. Sci. Rep. 9, 9277 (2019).
3. Allam, A., Dittberner, M., Sintsova, A., Brodbeck, D. & Krauthammer, M. Patient Similarity Analysis with Longitudinal Health Data. (2020). http://arxiv.org/abs/2005.06630

 

Qualifications

• PhD degree in computer science (focused on machine learning), optimization, statistics, applied math or closely related discipline.
• Strong publication record with at least one first-author paper in top-tier conferences (such as NeurIPS, ICML , AISTATS, AAAI, ICLR, etc.)
• Proficient in Python and the scientific computing stack (SciPy, Numpy, Scikit- learn, pandas)
• Proficient in one of the deep learning frameworks (PyTorch, Tensorflow)

 

What we offer

We offer an interdisciplinary research environment, the possibility to direct your own research and access to state-of-the-art computational resources infrastructure.

• Access to state-of-the-art infrastructure (computational resources), clinical datasets and medical expertise domain-knowledge (excellent medical doctors and research scientists)
• Ability to make a real and tangible impact in healthcare research
• Solve real-world problems and improve hospital-related processes and workflow
• Stimulating research environment and a place to grow academically and professionally
• Outstanding working conditions at the University of Zurich (more details here).

Please apply via Nature Careers

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13.02.2020

The Polymenidou lab has an open Postdoc position with flexible starting date.
Please send your application with CV, motivation letter and references to Magda and Julien.

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20.12.2019

The Krauthammer lab is currently looking for Master’s students in the field of bioinformatics for the following topics:

• Analyzing the effects of DNA secondary structure on the mutational pattern in cancer.
  The student will analyze the relationship between mutational patterns detected in various cancer types and the locations of non-B-DNA secondary structures in the human genome. The student should have basic experience with Unix systems and some experience with at least one scripting language (e.g. Python, R or bash). Prior experience with genomics software (mappers, samtools or variant callers) is an advantage.

• Mapping structural variation in cancer.
  The student will use genome sequencing data in order to discover novel structural variants in various cancer types (melanoma, colorectal carcinoma, lung cancer, etc.). The clinical significance of the novel and already known structural variants will also be evaluated using genome annotations. The student should have basic experience with Unix systems and some experience with at least one scripting language (e.g. Python). Prior experience with genomics software (mappers, samtools or variant callers) is an advantage.

Applications can be done by sending a CV to this e-mail along with a short description of the student’s motivation to join our lab.

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The Bodenmiller lab is seeking to fill several Master Student positions, with flexible starting date. These projects are in the field of

• Quantitative biology I: Simultaneous analysis of up to 100 markers in tumors using a new technology, called imaging mass cytometry [Link]
• Quantitative biology II: Analysis of how tumor cells become metastatic
• Computational biology: Computational analysis of signaling networks

Please send your CV and a few sentences why you would like to join our lab to Bernd Bodenmiller

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