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Department of Quantitative Biomedicine

The Bodenmiller group publishes their review on profiling cell signaling networks at single-cell resolution

Profiling cell signaling networks at single-cell resolution

© 2020 The Author(s)

Heterogeneity of signalling networks is at the basis of many biological processes, such as cell differentiation and drug resistance. Recent developments in multiplexed single-cell measurement technologies enabled evaluation of this heterogeneity. This review categorizes single-cell signaling network profiling approaches by their methodology, coverage, and application, and discusses the pros and cons of each technology. Furthermore, computational tools for network characterization using single-cell data are described. Finally, potential confounding factors that need to be considered in single-cell signaling network analyses are discussed.

See Lun & Bodenmiller, Molecular & Cellular Proteomics