High-Dimensional T Helper Cell Profiling Reveals a Broad Diversity of Stably Committed Effector States and Uncovers Interlineage Relationships
This study resulted from a collaboration with the research group of Prof. Dr. Manfred Kopf at ETH Zurich.;
CD4 + T helper (Th) are known to orchestrate immune responses. Based on the expression of signature cytokines and transcription factors, several Th subsets have previously been defined. In this study, CyTOF was used to systematically explore the diversity of Th cell responses generated both in vitro and in animal disease models, revealing a broad diversity in effector states with distinct cytokine footprints.