06.01.2023The Bodenmiller group publishes a single-cell map of T cell exhaustion-associated immune environments in breast cancer

Immune checkpoint therapy aims at preventing or reversing exhausted T cell states, but in breast cancer, T cell exhaustion is poorly understood. In this work, the Bodenmiller group used single-cell transcriptomics combined with imaging mass cytometry to systematically study immune environments of human luminal breast tumors with and without exhausted T cells. The data show that expression of PD-1 and CXCL13 on T cells, and MHC-I – but not PD-L1 – on tumor cells on tumor cells are powerful differentiators between these environments.
See Tietscher et al., Nat Communications