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Department of Quantitative Biomedicine

The Kümmerli group shows the potential of combining antivirulence drugs with antibiotics against an opportunistic human pathogen

Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa

This microbiology study reveals that compounds that disarm bacterial pathogens by targeting their virulence factors can be potent adjuvants to antibiotics, as they remain active against - and can reduce the selective advantage of - antibiotic resistant strains.

See Rezzoagli, Archetti et al., PLOS Biology

Figure 4 Rezzoagli et al 2020
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Figure 4: Drug interaction heatmaps for antibiotic-antivirulence combination treatments. © 2020 The Authors