Trafficking of protein aggregates through neural networks is known to cause propagation of pathology and toxicity in neurodegenerative diseases. Scheiblich et al. (2021) describe an advantageous aggregate-sharing strategy, challenging the view that pathological protein propagation only has a detrimental outcome on network longevity.
Spotlight article: Wiersma and Polymenidou, Neuron
Original publication: Scheiblling et al, Cell