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Department of Quantitative Biomedicine

The Bodenmiller group identifies prognostic single-cell populations in breast cancer lymph node metastases

Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers


In this work, the Bodenmiller group uses multiplex imaging mass cytometry to analyze breast cancer patients' single tumor cell phenotypes, both in primary tumors and in matched lymph node metastases. They report high phenotypic variability between these tissue sites and identify high- and low-risk disseminated cell phenotypes and prognostic markers.
See Fischer et al., Cell Reports Medicine