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Department of Quantitative Biomedicine

The Kümmerli group and collaborators publish a high-throughput method to elucidate siderophores from natural Pseudomonas

A comprehensive method to elucidate pyoverdines produced by fluorescent Pseudomonas spp. by UHPLC-HR-MS/MS

This work resulted from a collaboration with the research group of Prof. Laurent Bigler at the University of Zurich's Institute for Chemistry.

Microorganisms produce secondary metabolites, which are low molecular weight compounds with various bioactive properties that play key roles in microbial physiology, growth and survival. In recent years, interest in microbial secondary metabolites has surged, owing to their potential as a source for drug discovery, as well as their application in agriculture and as biosurfactants. This work presents a novel UHPLC-MS/MS-based method for the high-throughput characterisation of the secondary metabolites pyoverdines from crude bacterial extracts.

See Rehm et al, Analytical and Bioanalytical Chemistry

Graphical abstract Rehm et al © 2022 The Authors