TIGIT promotes tissue repair in T cells
A new study from the Joller Lab at DQBM uncovers that the co-inhibitory receptor TIGIT not only limits immune pathology but also directly promotes tissue repair. Using viral infection models, the researchers show that TIGIT drives the expression of amphiregulin (Areg), a key tissue growth factor, in regulatory T cells. This tissue-protective mechanism is distinct from classical immunosuppression and relies on the transcription factor Blimp-1 downstream of TIGIT signaling. The findings highlight a dual role for TIGIT in immune regulation and regeneration, offering insights into how T cells maintain tissue homeostasis during infection.