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Department of Quantitative Biomedicine

Nicole Joller

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Immunological aspects of host-pathogen interactions

Our understanding of host-pathogen interaction is primarily derived from studying how the immune system protects us from a single pathogen. In contrast, it is largely unknown how this response alters the body’s ability to respond to a second infectious agent or the susceptibility to autoimmunity or cancer. Our goal is to investigate the long-term effects of pathogenic challenges on future responses. Currently, we are focusing on changes in the regulatory compartment of the adaptive immune system. 

Specifically we aim to:

  1. Analyze how regulatory T cell (Treg) function and the composition of the Treg compartment are affected by different types of infections;
  2. Determine how alterations in the Treg compartment affect susceptibility to infections and autoimmunity;
  3. Investigate how previous infections affect the susceptibility to an unrelated secondary challenge (read our recent review);
  4. Investigate how co-inhibitory receptors affect immune control of pathogens.

To achieve this goal we use a wide variety of techniques including:
transcriptomics, high dimensional flow cytometry, in vitro and in vivo immunological assays, animal models (infectious and autoimmune).

Short CV Prof. Dr. Nicole Joller

Since 2022 Professor for Immunology, DQBM, UZH, Switzerland
2014-2021 SNSF/ERC Assistant Professor, Institute for Experimental Immunology, UZH, Switzerland
2009-2014 Postdoctoral Research Fellow, Harvard Medical School; Brigham & Women's Hospital; Broad Institute of MIT and Harvard; Boston, USA
Prof. Dr. Vijay Kuchroo
2004-2008 PhD in Immunology, ETH Zurich, Switzerland
Prof. Dr. Annette Oxenius
1998-2003 Diploma in Natural Sciences (Biochemistry), ETH Zurich, Switzerland

These funding agencies support the Joller group:

Funding Nicole Joller

Weiterführende Informationen

Prof. Dr. Nicole Joller

Prof. Dr. Nicole Joller - Professor for Immunology

Department of Quantitative Biomedicine
University of Zurich
Winterthurerstrasse 190
CH-8057 Zurich

Building / Room: Y36-L-68
phone: +41 44 635 49 45


Administrative Assistant:
Denise Harsch
Building/Room: Y38-M-02
phone: +41 44 635 6538